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Salvianolic acid A

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Catalog No. T6S0444Cas No. 96574-01-5
Alias Dan Phenolic Acid A

Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.

Salvianolic acid A

Salvianolic acid A

🥰Excellent
Purity: 100%
Catalog No. T6S0444Alias Dan Phenolic Acid ACas No. 96574-01-5
Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.
Pack SizePriceAvailabilityQuantity
5 mg$45In Stock
10 mg$72In Stock
25 mg$146In Stock
50 mg$217In Stock
100 mg$326In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier.
In vitro
METHODS: Five tumor cell lines, SKOV3, HeLa, NCI-H1975, DU145 and A549, were treated with Salvianolic acid A (1.56-100 µM) for 72 h. Cell viability was measured by CellTiter-Glo kit.
RESULTS: The growth of SKOV3, HeLa, NCI-H1975, DU145 and A549 cells was inhibited with increasing concentrations of Salvianolic acid A, with IC50s of 30.84 µM, 15.85 µM, 10.19 µM, 9.512 µM and 6.461 µM, respectively. [1]
METHODS: Rat cardiomyocytes H9C2 were treated with Salvianolic acid A (50 µM) and Doxorubicin (4 µM) for 12 h. Apoptosis was detected by TUNEL assay.
RESULTS: The number of apoptotic cells increased significantly after Dox stimulation. H9C2 cells co-treated with Dox and Salvianolic acid A exhibited significantly lower apoptosis rates compared to cells exposed to Dox. Salvianolic acid A inhibited Dox-induced apoptosis in H9C2 cells. [2]
In vivo
METHODS: In order to investigate the effects on amnesia in mice, Salvianolic acid A (10-40 mg/kg) was administered orally once daily for five days to a C57BL/6 mouse model of amnesia induced by diazepam.
RESULTS: Salvianolic acid A exerts an antiamnesic effect on diazepam-induced paracrine amnesia in mice by enhancing the antioxidant capacity of the hippocampus. [3]
AliasDan Phenolic Acid A
Chemical Properties
Molecular Weight494.45
FormulaC26H22O10
Cas No.96574-01-5
SmilesOC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1\C=C\c1ccc(O)c(O)c1
Relative Density.1.580 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (91.01 mM)
10% DMSO+90% Saline: 13 mg/mL (26.29 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
Ethanol: 10 mg/mL
Solution Preparation Table
10% DMSO+90% Saline/DMSO
1mg5mg10mg50mg
1 mM2.0224 mL10.1122 mL20.2245 mL101.1225 mL
5 mM0.4045 mL2.0224 mL4.0449 mL20.2245 mL
10 mM0.2022 mL1.0112 mL2.0224 mL10.1122 mL
20 mM0.1011 mL0.5056 mL1.0112 mL5.0561 mL
DMSO
1mg5mg10mg50mg
50 mM0.0404 mL0.2022 mL0.4045 mL2.0224 mL

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