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Scutellarin

Catalog No. T2789 CAS 27740-01-8

Synonyms: Breviscapin, Breviscapinun, Breviscapine, Scutellarein-7-glucuronide

Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signaling in HCC cells.

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Scutellarin, CAS 27740-01-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 45.00
25 mg	In stock	$ 77.00
50 mg	In stock	$ 134.00
100 mg	In stock	$ 173.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.32%

Purity: 98.64%

Purity: 98.28%

Purity: 96.85%

Purity: 95.86%

Biological Description

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Description	Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signaling in HCC cells.
In vitro	Scutellarin significantly lowers HepG2 cell viability in a dose-dependent manner and hampers HCC cells' migration and invasion in vitro. It notably decreases STAT3 and Girdin expression, along with the phosphorylation of STAT3 and Akt in HCC cells. The overexpression of STAT3 reverses the suppression by scutellarin of Girdin expression and Akt activation, restoring HCC cells' ability to migrate and invade. Furthermore, overexpression of Girdin nullifies scutellarin's inhibitory effects on Akt phosphorylation, and on the migration and invasion of HCC cells. Scutellarin can prevent HCC cell metastasis in vivo and restrict their migration and invasion in vitro by targeting the STAT3/Girdin/Akt pathway. Additionally, scutellarin has a neuroprotective role by inhibiting microglial activation, mitigating neuroinflammation, and promoting astrocytic response by upregulating neurotrophic factor expression. This demonstrates a beneficial interaction between activated microglia and astrocytes. Scutellarin also impedes RANKL-mediated osteoclastogenesis and bone resorption by reducing osteoclast-specific gene expression (TRAP, cathepsin K, c-Fos, NFATc1) and inhibiting the RANKL-mediated MAPK and NF-κB signaling pathways, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation.
In vivo	Scutellarin administration at a dosage of 50 mg/kg/day notably reduces both lung and intrahepatic metastasis of HCC tumors in vivo. Comparatively, the scutellarin-treated group exhibits a significant decrease in the number of metastatic tumors in the lung and liver versus the control group[1]. Furthermore, rats receiving Scutellarin show marked improvement in neurobehavioral deficits in contrast to the SAH group, alongside an enhancement in eNOS expression[4].
Cell Research	HepG2 cells (1×105/well) are cultured in 96-well plates and treated in triplicate with scutellarin at concentrations of 5, 10, 20, 30, and 100 μM or vehicle alone for 24 h. The cellular viability is tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and is expressed as a percentage of proliferation versus controls.
Source	Natural Products > Lamiaceae > Scutellaria

Synonyms	Breviscapin, Breviscapinun, Breviscapine, Scutellarein-7-glucuronide
Molecular Weight	462.36
Formula	C21H18O12
CAS No.	27740-01-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50mg/mL(108.14 mM)

References and Literature

1. Ke Y, et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochem Biophys Res Commun. 2016 Dec 18. pii: S0006-291X(16)32174-X. 2. Yang LL, et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. Biochim Biophys Acta. 2016 Nov 27;1863(2):598-606. 3. Wu CY, et al. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia - a therapeutic consideration. Curr Med Chem. 2016 Nov 18. [Epub ahead of print] 4. Li Q, et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. J Clin Neurosci. 2016 Dec;34:264-270. 5. Zhao, S., Sun, Y., Li, X., Wang, J., Yan, L., & Zhang, Z. et al. (2016). Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. International Immunopharmacology, 40, 458-465. doi: 10.1016/j.intimp.2016.09.031 6. Chinnasamy S, Selvaraj G, Selvaraj C, et al. Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2)[J]. International Journal of Biological Macromolecules. 2020, 144: 53-66

Citations

1. Chinnasamy S, Selvaraj G, Selvaraj C, et al. Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2). International Journal of Biological Macromolecules. 2020, 144: 53-66 2. Yang X, Liu L, Hao Y, et al. A Bioluminescent Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and In Vitro. Viruses. 2021, 13(6): 1055.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Glycolysis Compound Library Anti-Lung Cancer Compound Library Ferroptosis Compound Library Anti-Infection Compound Library Anti-Fibrosis Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Cancer Metabolism Compound Library Tibetan medicine Compound Library

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Keywords

Scutellarin 27740-01-8 Cytoskeletal Signaling JAK/STAT signaling Microbiology/Virology PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Akt HIV Protease STAT PKB Inhibitor inhibit HIV Protein kinase B Human immunodeficiency virus Breviscapin Breviscapinun Breviscapine Scutellarein-7-glucuronide inhibitor

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