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Shogaol

Catalog No. T6S1699   CAS 555-66-8
Synonyms: [6]-Shogaol, 6-Shogaol

1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats. 3. 6-Shogaol inhibits the growth of human cancer cells and induces apoptosis in COLO 25 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). 4. 6-Shogaol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis, could further regulate urokinase-type plasminogen activity.

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Shogaol Chemical Structure
Shogaol, CAS 555-66-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
5 mg In stock $ 63.00
10 mg In stock $ 98.00
25 mg In stock $ 198.00
50 mg In stock $ 311.00
100 mg In stock $ 476.00
1 mL * 10 mM (in DMSO) In stock $ 68.00
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Purity: 99.39%
Purity: 99.03%
Purity: 98.26%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the femoral cartilage from damage produced in a CFA monoarthritic model of the knee joint of rats. 3. 6-Shogaol inhibits the growth of human cancer cells and induces apoptosis in COLO 25 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). 4. 6-Shogaol effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis, could further regulate urokinase-type plasminogen activity.
Source
Synonyms [6]-Shogaol, 6-Shogaol
Molecular Weight 276.37
Formula C17H24O3
CAS No. 555-66-8

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (199.01 mM)

TargetMolReferences and Literature

1. Han M A , Woo S M , Min K J , et al. 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression[J]. Chem Biol Interact, 2015, 228:69-78.

TargetMolCitations

1. Zhang B, Zhao J, Wang Z, et al. Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation. Frontiers in Pharmacology. 2021:1781 2. Kamaruddin M S H, Chong G H, Umanan F, et al.Enhancement of 6-gingerol extraction from Bentong ginger using supercritical carbon dioxide.Journal of CO2 Utilization.2023, 72: 102505.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Angiogenesis related Compound Library Covalent Inhibitor Library Inhibitor Library Ferroptosis Compound Library Traditional Mongolian Medicine Compound Library Natural Product Library for HTS Natural Product Library Anti-Fibrosis Compound Library Oxidation-Reduction Compound Library

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Keywords

Shogaol 555-66-8 Autophagy Metabolism Lipoxygenase Inhibitor [6]-Shogaol inhibit 6-Shogaol inhibitor

 

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