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Sinefungin

Catalog No. T16886   CAS 58944-73-3
Synonyms: Adenosyl-Ornithine, A-9145, Antibiotic 32232RP

Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.

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Sinefungin Chemical Structure
Sinefungin, CAS 58944-73-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 129.00
5 mg In stock $ 313.00
10 mg In stock $ 497.00
25 mg In stock $ 1,060.00
50 mg In stock $ 1,860.00
100 mg In stock $ 3,270.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.
In vitro Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA. It also inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells [2].
In vivo In obstructive nephropathy, Sinefungin (10 mg/kg, per day immediately after UUO) improves renal fibrosis [2].
Synonyms Adenosyl-Ornithine, A-9145, Antibiotic 32232RP
Molecular Weight 381.39
Formula C15H23N7O5
CAS No. 58944-73-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 95 mg/mL (249.09 mM), sonification is recommended.

TargetMolReferences and Literature

1. Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7. 2. Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15.

Related compound libraries

This product is contained In the following compound libraries:
Epigenetics Compound Library

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SW2_110A UNC 0631 OTS186935 FA WDR5-47 MS0124 GSK126 YM458 MM-102 TFA

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Keywords

Sinefungin 58944-73-3 Chromatin/Epigenetic Microbiology/Virology Others Histone Methyltransferase Antifungal Antibiotic UUP collagen 3 inhibit Adenosyl-Ornithine H3K4 α-SMA FSP-1 A 9145 Fungal Inhibitor A9145 A-9145 Antibiotic 32232RP collagen 1 inhibitor

 

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