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Solithromycin

Solithromycin
Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemophilus influenzae with IC50 values of 7.5 ng/mL, 40 ng/mL, and 125 ng/mL, respectively.Solithromycin inhibits protein biosynthesis by binding to the large 50S subunit of the ribosome.
Catalog No. T2331Cas No. 760981-83-7
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Purity:99.42%
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Solithromycin

Catalog No. T2331Cas No. 760981-83-7
Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemophilus influenzae with IC50 values of 7.5 ng/mL, 40 ng/mL, and 125 ng/mL, respectively.Solithromycin inhibits protein biosynthesis by binding to the large 50S subunit of the ribosome.
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Pack SizePriceAvailabilityQuantity
2 mg$32In Stock
5 mg$51In Stock
10 mg$89In Stock
25 mg$178In Stock
50 mg$293In Stock
1 mL x 10 mM (in DMSO)$82In Stock
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Product Introduction

Bioactivity
Description
Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemophilus influenzae with IC50 values of 7.5 ng/mL, 40 ng/mL, and 125 ng/mL, respectively.Solithromycin inhibits protein biosynthesis by binding to the large 50S subunit of the ribosome.
Targets&IC50
S. aureus:40 ng/ml, Haemophilus influenzae:125 ng/ml, Streptococcus pneumoniae:7.5 ng/ml
AliasOP-1068, CEM-101
Chemical Properties
Molecular Weight845.01
FormulaC43H65FN6O10
Cas No.760981-83-7
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (59.17 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1834 mL5.9171 mL11.8342 mL59.1709 mL
5 mM0.2367 mL1.1834 mL2.3668 mL11.8342 mL
10 mM0.1183 mL0.5917 mL1.1834 mL5.9171 mL
20 mM0.0592 mL0.2959 mL0.5917 mL2.9585 mL
50 mM0.0237 mL0.1183 mL0.2367 mL1.1834 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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