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Su1498

Catalog No. T3980   CAS 168835-82-3
Synonyms: Tyrphostin SU 1498, AG 1498

Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Su1498 Chemical Structure
Su1498, CAS 168835-82-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 47.00
5 mg In stock $ 72.00
10 mg In stock $ 122.00
25 mg In stock $ 233.00
50 mg In stock $ 346.00
100 mg In stock $ 513.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.54%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
Targets&IC50 VEGFR2:700 nM
Synonyms Tyrphostin SU 1498, AG 1498
Molecular Weight 390.52
Formula C25H30N2O2
CAS No. 168835-82-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (384.10 mM)

TargetMolReferences and Literature

1. Gawlak G, et al. Chronic high-magnitude cyclic stretch stimulates EC inflammatory response via VEGF receptor 2-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1062-70.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Breast Cancer Compound Library Covalent Inhibitor Library Anti-Pancreatic Cancer Compound Library Angiogenesis related Compound Library Inhibitor Library Anti-Fibrosis Compound Library Anti-Cardiovascular Disease Compound Library Anti-Liver Cancer Compound Library Cytokine Inhibitor Library

Related Products

Related compounds with same targets
hCA/VEGFR-2-IN-4 Sorafenib SU11274 Sitravatinib Acrizanib Ponatinib Hydrochloride Lenvatinib mesylate TAK-593

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Keywords

Su1498 168835-82-3 Angiogenesis Tyrosine Kinase/Adaptors VEGFR Vascular endothelial growth factor receptor Inhibitor Su-1498 Tyrphostin SU 1498 inhibit AG1498 AG-1498 Tyrphostin SU-1498 Tyrphostin SU1498 SU 1498 AG 1498 inhibitor

 

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