Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 229.00 | |
50 mg | In stock | $ 412.00 | |
100 mg | In stock | $ 589.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 136.00 |
Description | T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2). |
Targets&IC50 | hSGLT1:22.8 μM (IC50), hSGLT2:2.3 μM (IC50) |
In vivo | Administration of 0.03% and 0.1% (wt/wt diet) T-1095 to STZ rats for 4 weeks improved the hyperglycemia and dose-dependently decreased HbA1c[1]. Moreover, treatment with 0.1% (wt/wt diet) T-1095 in STZ rats for 8 weeks not only reduced blood glucose and HbA1c, levels but also prevented the elevation of urinary albumin levels and kidney weight and the development of epithelial vacuolation[1]. The expression of renal SGLT2, a major glucose transporter in the kidney, was not different in normal, STZ, and T-1095-treated STZ rats. In contrast, the elevated renal GLUT2 level in STZ rats was suppressed by T-1095[1]. |
Molecular Weight | 516.49 |
Formula | C26H28O11 |
CAS No. | 209746-59-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (116.17 mM)
You can also refer to dose conversion for different animals. More
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T-1095 209746-59-8 GPCR/G Protein Metabolism transporter SGLT SGLT1 Sodium-dependent glucose cotransporters antidiabetic SGLT2 Inhibitor orally active T1095 inhibit T 1095 inhibitor