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TAK-615

Catalog No. T9699 CAS 1664335-55-0

TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.

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TAK-615, CAS 1664335-55-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 287.00
10 mg	In stock	$ 455.00
25 mg	In stock	$ 753.00
50 mg	In stock	$ 1,060.00
100 mg	In stock	$ 1,430.00
500 mg	In stock	$ 2,860.00
1 mL * 10 mM (in DMSO)	In stock	$ 318.00

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Biological Description

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Description	TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
In vitro	TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity of 1.7 ± 0.5 nM and Kd low affinity of 14.5 ± 12.1 nM. TAK-615 is only able to partically inhibit the LPA response (~40% at 10 μM with an IC50 of 23 ± 13 nM in β-arrestin assay; 60% at 10 μM, IC50 of 91 ± 30 nM in calcuim mobilisation assay). [1]

Molecular Weight	419.44
Formula	C25H22FNO4
CAS No.	1664335-55-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (286.10 mM), Sonication is recommended.

References and Literature

1. Jonathan Ellery, et al. Identification of compounds acting as negative allosteric modulators of the LPA 1 receptor. Eur J Pharmacol. 2018 Aug 15;833:8-15.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TAK-615 1664335-55-0 GPCR/G Protein LPA Receptor LPA1 fibrosis LPL Receptor Lysophospholipid Receptor modulator TAK 615 NAM TAK615 inhibit pulmonary Inhibitor allosteric negative inhibitor

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