Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

TP0427736

Catalog No. T24897Cas No. 864374-00-5
Alias TP-427736, TP427736, TP-0427736

TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.

TP0427736

TP0427736

Purity: 97.67%
Catalog No. T24897Alias TP-427736, TP427736, TP-0427736Cas No. 864374-00-5
TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
5 mg$238In Stock
10 mg$389In Stock
25 mg$663In Stock
50 mg$945In Stock
1 mL x 10 mM (in DMSO)$269In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "TP0427736"

Select Batch
Purity:97.67%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates the anagen phase i
Targets&IC50
ALK5:2.72 nM
AliasTP-427736, TP427736, TP-0427736
Chemical Properties
Molecular Weight298.39
FormulaC14H10N4S2
Cas No.864374-00-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/ml (217.84 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3513 mL16.7566 mL33.5132 mL167.5659 mL
5 mM0.6703 mL3.3513 mL6.7026 mL33.5132 mL
10 mM0.3351 mL1.6757 mL3.3513 mL16.7566 mL
20 mM0.1676 mL0.8378 mL1.6757 mL8.3783 mL
50 mM0.0670 mL0.3351 mL0.6703 mL3.3513 mL
100 mM0.0335 mL0.1676 mL0.3351 mL1.6757 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy TP0427736 | purchase TP0427736 | TP0427736 cost | order TP0427736 | TP0427736 chemical structure | TP0427736 formula | TP0427736 molecular weight