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TP0427736

TP0427736
TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
Catalog No. T24897Cas No. 864374-00-5
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Purity:97.67%
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TP0427736

Purity: 97.67%
Catalog No. T24897Alias TP-427736, TP427736, TP-0427736Cas No. 864374-00-5

TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
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Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
5 mg$238In Stock
10 mg$389In Stock
25 mg$663In Stock
50 mg$945In Stock
1 mL x 10 mM (in DMSO)$269In Stock
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Product Introduction

Bioactivity
Description
TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates the anagen phase i
Targets&IC50
ALK5:2.72 nM
AliasTP-427736, TP427736, TP-0427736
Chemical Properties
Molecular Weight298.39
FormulaC14H10N4S2
Cas No.864374-00-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/ml (217.84 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3513 mL16.7566 mL33.5132 mL167.5659 mL
5 mM0.6703 mL3.3513 mL6.7026 mL33.5132 mL
10 mM0.3351 mL1.6757 mL3.3513 mL16.7566 mL
20 mM0.1676 mL0.8378 mL1.6757 mL8.3783 mL
50 mM0.0670 mL0.3351 mL0.6703 mL3.3513 mL
100 mM0.0335 mL0.1676 mL0.3351 mL1.6757 mL

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