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Tafluprost

Catalog No. TQ0203   CAS 209860-87-7
Synonyms: MK2452, AFP-168

Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.

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Tafluprost Chemical Structure
Tafluprost, CAS 209860-87-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
2 mg In stock $ 51.00
5 mg In stock $ 79.00
10 mg In stock $ 97.00
25 mg In stock $ 159.00
50 mg In stock $ 233.00
100 mg In stock $ 345.00
500 mg In stock $ 832.00
1 mL * 10 mM (in DMSO) In stock $ 87.00
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Purity: 99.16%
Purity: 97.7%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.
In vivo Tafluprost showed significant IOP-lowering effects without any safety concerns in patients with various types of glaucoma and OH in daily clinical practice and tafluprost is highly effective in any therapeutic pattern [1]. Tafluprost with reduced BAK has potential as a superior antiglaucoma drug, not only for its IOP-lowering effect but also for its good corneal safety profile [2]. Tafluprost single-use vials treatment was effective in reducing IOP over the 3 years of this study, but visual field performance worsened by 10.3%-13.8% in patients with normal-tension glaucoma [3].
Synonyms MK2452, AFP-168
Molecular Weight 452.53
Formula C25H34F2O5
CAS No. 209860-87-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (552.45 mM)

TargetMolReferences and Literature

1. Kuwayama, Y. and A. Nomura, Prospective observational post-marketing study of tafluprost for glaucoma and ocular hypertension: short-term efficacy and safety. Adv Ther, 2014. 31(4): p. 461-71. 2. Kumagami, T., et al., Comparison of corneal safety and intraocular pressure-lowering effect of tafluprost ophthalmic solution with other prostaglandin ophthalmic solutions. J Ocul Pharmacol Ther, 2014. 30(4): p. 340-5. 3. Inoue, K., A. Tanaka, and G. Tomita, Effects of tafluprost treatment for 3 years in patients with normal-tension glaucoma. Clin Ophthalmol, 2013. 7: p. 1411-6.

TargetMolCitations

1. Wu S, Liu C, Tang J, et al.Tafluprost promotes axon regeneration after optic nerve crush via Zn2+-mTOR pathway.Neuropharmacology.2023: 109746.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library ReFRAME Related Library RO5 Drug-like Natural Product Library Anti-Hypertension Compound Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Endocrinology-Hormone Compound Library Bioactive Lipid Compound Library

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Keywords

Tafluprost 209860-87-7 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor inhibit MK2452 AFP-168 AFP 168 AFP168 Inhibitor MK 2452 MK-2452 inhibitor

 

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