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Talniflumate

Catalog No. T4503 CAS 66898-62-2

Synonyms: inhibit, asthma, cystic fibrosis, Talniflumate, Inhibitor, pulmonary, obstructive, Chloride Channel, anti-inflammatory, BA 7602-06, Somalgen, COPD, Cl? Channels, chronic, ulcerogenic, Intestinal disease, analgesic

Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.

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Talniflumate, CAS 66898-62-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	inhibit, asthma, cystic fibrosis, Talniflumate, Inhibitor, pulmonary, obstructive, Chloride Channel, anti-inflammatory, BA 7602-06, Somalgen, COPD, Cl? Channels, chronic, ulcerogenic, Intestinal disease, analgesic
Molecular Weight	414.34
Formula	C21H13F3N2O4
CAS No.	66898-62-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Knight D. Talniflumate (Genaera)[J]. Current Opinion in Investigational Drugs, 2004, 5(5):557-62. 2. Walker N M, et al. Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.[J]. Journal of Pharmacology & Experimental Therapeutics, 2006, 317(1):275-83.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cardiovascular Disease Compound Library Inhibitor Library Ion Channel Inhibitor Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Nonsteroidal Anti-Inflammatory Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Fibrosis Compound Library

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Talniflumate

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.