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Talniflumate

Catalog No. T4503 CAS 66898-62-2

Synonyms: Somalgen, Somalgen

Purity 98.00% Datasheet

Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.

Talniflumate, CAS 66898-62-2

Pack Size	Availability	Price/USD
2 mg	In stock	50.00
5 mg	In stock	80.00
1 mL * 10 mM (in DMSO)	In stock	80.00

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Purity 98.00%

HNMR COA Datasheet MSDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.
Targets&IC50

Synonyms	Somalgen , Somalgen
Purity	98.00%
Molecular Weight	414.33
Formula	C21H13F3N2O4
CAS No.	66898-62-2

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 10 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Knight D. Talniflumate (Genaera)[J]. Current Opinion in Investigational Drugs, 2004, 5(5):557-62. 2. Walker N M, et al. Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.[J]. Journal of Pharmacology & Experimental Therapeutics, 2006, 317(1):275-83.

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