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Tamolarizine
Catalog No. T34782Cas No. 93035-32-6
Alias Tamolarizine HCl, Tamolarizine free base, Tamolarizine dihyrchloride, Tamolarizine, NC-1100, NC1100, NC 1100
Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.
Tamolarizine
Catalog No. T34782Alias Tamolarizine HCl, Tamolarizine free base, Tamolarizine dihyrchloride, Tamolarizine, NC-1100, NC1100, NC 1100Cas No. 93035-32-6
Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $143 | In Stock | |
| 5 mg | $360 | In Stock | |
| 10 mg | $530 | In Stock | |
| 25 mg | $859 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,590 | In Stock | |
| 500 mg | $3,190 | In Stock |
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Purity:98.17%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist. |
| In vitro | Tamolarizine (0.1-10 microM) synergistically potentiated the cytotoxicity of doxorubicin for doxorubicin-resistant K562 cells (K562/DXR), but had hardly any synergistic effects in the parental cell line (K562) at the same concentration. Moreover, tamolarizine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner and reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay.[1] |
| In vivo | Tamolarizine (40 mg/kg; rats; immediately after 15-min brain ischemia) showed slight impairment of place learning during the course of this test, they later reached almost the same performance level as the sham-operated group. Selective neuronal loss in the CA1 subfield was much less in the ischemia+tamolarizine group than in the ischemia+saline group. These results indicate that tamolarizine treatment protects the hippocampus from ischemic brain damage and ameliorates place learning impairment.[2] |
| Alias | Tamolarizine HCl, Tamolarizine free base, Tamolarizine dihyrchloride, Tamolarizine, NC-1100, NC1100, NC 1100 |
| Molecular Weight | 432.55 |
| Formula | C27H32N2O3 |
| Cas No. | 93035-32-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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