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Tarafenacin D-tartrate

Catalog No. T16989Cas No. 1159101-48-0
Alias SVT-40776 D-tartrate

Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a selective and potent muscarinic acetylcholine M3 receptor antagonist used in the study of overactive bladder and bronchial disorders.

Tarafenacin D-tartrate

Tarafenacin D-tartrate

Purity: 99.86%
Catalog No. T16989Alias SVT-40776 D-tartrateCas No. 1159101-48-0
Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a selective and potent muscarinic acetylcholine M3 receptor antagonist used in the study of overactive bladder and bronchial disorders.
Pack SizePriceAvailabilityQuantity
2 mg$127In Stock
5 mg$2175 days
25 mg$6906-8 weeks
50 mg$8976-8 weeks
100 mg$1,5206-8 weeks
1 mL x 10 mM (in DMSO)$3735 days
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Purity:99.86%
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Product Introduction

Bioactivity
Description
Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a selective and potent muscarinic acetylcholine M3 receptor antagonist used in the study of overactive bladder and bronchial disorders.
In vitro
D-tartrate Tarafenacin was more selective for M(3) receptors than for M(2) receptors (Ki = 0.19 nmol.L(-1) for M(3) receptor affinity). Of the anticholinergic drugs tested, tarafenacin tartrate had the strongest inhibitory effect on carbachol-induced bladder contraction but did not affect atrial contraction over the same concentration range. Tarafenacin D-tartrate had the highest selectivity (199-fold) for urine and heart.The binding affinity of tarafenacin D-tartrate for the M5 mAChR (K(d) = 0.4 nM) was much higher than that of solifenacin (K(d) = 31 nM) for the same receptor.The binding affinity of tarafenacin D-tartrate for the M5 mAChR was much higher than that for solifenacin (K(d) = 31 nM). The calculated change in free energy of binding from solifenacin to tarafenacin tartrate (-2.3 ± 0.3 kcal/mol) agrees well with the experimentally derived change in free energy of binding (-2.58 kcal/mol), suggesting that our modeled structure of the M5 mAChR and its complex with the antagonist is reliable [1][2].
In vivo
Tarafenacin D-tartrate inhibited 25% of spontaneous bladder contractions at a very low dose (6.97 microg.kg(-1) i.v) in the guinea pig in vivo model, without affecting arterial blood pressure [1].
AliasSVT-40776 D-tartrate
Chemical Properties
Molecular Weight558.48
FormulaC25H26F4N2O8
Cas No.1159101-48-0
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (143.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7906 mL8.9529 mL17.9057 mL89.5287 mL
5 mM0.3581 mL1.7906 mL3.5811 mL17.9057 mL
10 mM0.1791 mL0.8953 mL1.7906 mL8.9529 mL
20 mM0.0895 mL0.4476 mL0.8953 mL4.4764 mL
50 mM0.0358 mL0.1791 mL0.3581 mL1.7906 mL
100 mM0.0179 mL0.0895 mL0.1791 mL0.8953 mL

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