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Tenovin-6

Catalog No. T1818 CAS 1011557-82-6

Synonyms: Tenovin 6

Tenovin-6 is a p53 transcriptional activity agonist.

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Tenovin-6, CAS 1011557-82-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
2 mg	In stock	$ 51.00
5 mg	In stock	$ 70.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 159.00
50 mg	In stock	$ 243.00
100 mg	In stock	$ 413.00
500 mg	In stock	$ 979.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 100%

Purity: 97.71%

Biological Description

Chemical Properties

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Description	Tenovin-6 is a p53 transcriptional activity agonist.
Targets&IC50	SIRT1:21 μM, SIRT3:67 μM, SIRT2:10 μM
In vivo	Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1].
Kinase Assay	Assays are carried out using purified components in the Fluor de Lys Fluorescent Assay Systems. Relevant FdL substrates are used at 7 μM and NAD+ at 1 mM. Tenovins are solubilized in DMSO with the final DSMO concentration in the reaction being less than 0.25%. For SirT1 and HDAC8, one unit of enzyme is used per reaction, and for SirT2 and SirT3, five units is used per reaction. Reactions are carried out at 37°C for 1 hr.
Cell Research	The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20?μM for 68?h, and then MTS is added at 20?μL/well to be read at a wave length of 490?nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve.

Synonyms	Tenovin 6
Molecular Weight	454.63
Formula	C25H34N4O2S
CAS No.	1011557-82-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 91 mg/mL (200.2 mM)

H2O: 90 mg/mL (198 mM)

References and Literature

1. Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Lipid Compound Library PPI Inhibitor Library Epigenetics Compound Library Pyroptosis Compound Library Anti-Diabetic Compound Library Chromatin Modification Compound Library Ubiquitination Compound Library Apoptosis Compound Library Glutamine Metabolism Compound Library Reprogramming Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tenovin-6 1011557-82-6 Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Sirtuin Dehydrogenase Dihydroorotate Dehydrogenase Inhibitor MDM-2/p53 MDM2 Tenovin6 acetylation degradation DHODH Tenovin 6 inhibit protein-deacetylating inhibitor

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