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Tigloylgomisin H

Catalog No. TN2272 CAS 66069-55-4

Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies.

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Tigloylgomisin H, CAS 66069-55-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 339.00
25 mg	In stock	$ 566.00
50 mg	In stock	$ 791.00
100 mg	In stock	$ 1,090.00
1 mL * 10 mM (in DMSO)	In stock	$ 267.00

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Description	Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies.
In vitro	In the current study, nine lignans were isolated from S. chinensis and tested for their ability to induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H (TGH) and angeloylgomisin H (AGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) (10.80 and 4.59, respectively) as compared to control. TGH also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, TGH significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.
Source	Natural Products > Schisandraceae > Schisandra

Molecular Weight	500.58
Formula	C28H36O8
CAS No.	66069-55-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (99.88 mM)

References and Literature

1. Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Tumor Natural Product Library Selected Plant-Sourced Compound Library Transcription Factor-Targeted Compound Library Traditional Chinese Medicine Monomer Library Anti-Cancer Compound Library NF-κB Signaling Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Natural Product Library for HTS Bioactive Compound Library

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Keywords

Tigloylgomisin H 66069-55-4 Immunology/Inflammation Nrf2 inhibit Inhibitor inhibitor

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