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VER-49009

Catalog No. T3454Cas No. 558640-51-0
Alias CCT 129397

VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).

VER-49009

VER-49009

Purity: 99.99%
Catalog No. T3454Alias CCT 129397Cas No. 558640-51-0
VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
Pack SizePriceAvailabilityQuantity
2 mg$38In Stock
5 mg$58In Stock
10 mg$93In Stock
25 mg$167In Stock
50 mg$273In Stock
100 mg$373In Stock
200 mg$527In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Purity:99.99%
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Product Introduction

Bioactivity
Description
VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
Targets&IC50
HSP90:25 nM, HSP90:78 nM(kd)
In vitro
VER-49009 inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells[1].
In vivo
Treatmented with VER-49009 results in clear depletion of ERBB2 at 3 and 8 h following the final dose, with client protein levels returning to normal by 24 h, in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors[2].
Kinase Assay
Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe.
Cell Research
Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference)
AliasCCT 129397
Chemical Properties
Molecular Weight387.82
FormulaC19H18ClN3O4
Cas No.558640-51-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (257.85 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5785 mL12.8926 mL25.7852 mL128.9258 mL
5 mM0.5157 mL2.5785 mL5.1570 mL25.7852 mL
10 mM0.2579 mL1.2893 mL2.5785 mL12.8926 mL
20 mM0.1289 mL0.6446 mL1.2893 mL6.4463 mL
50 mM0.0516 mL0.2579 mL0.5157 mL2.5785 mL
100 mM0.0258 mL0.1289 mL0.2579 mL1.2893 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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