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Vofopitant dihydrochloride
Catalog No. T13329LCas No. 168266-51-1
Alias Vofopitant 2HCl, GR 205171A
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively. It is a potential compound for the treatment of pathological vomiting.
Vofopitant dihydrochloride
Catalog No. T13329LAlias Vofopitant 2HCl, GR 205171ACas No. 168266-51-1
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively. It is a potential compound for the treatment of pathological vomiting.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $100 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $749 | In Stock | |
| 50 mg | $1,120 | In Stock | |
| 100 mg | $1,530 | In Stock | |
| 500 mg | $2,970 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $275 | In Stock |
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ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively. It is a potential compound for the treatment of pathological vomiting. |
| Targets&IC50 | NK1 (rat):9.5 (pKi), NK1 (human):10.6 (pKi) |
| Alias | Vofopitant 2HCl, GR 205171A |
| Molecular Weight | 505.36 |
| Formula | C21H25Cl2F3N6O |
| Cas No. | 168266-51-1 |
Storage & Solubility Information
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 20 mg/mL (39.58 mM), Sonication is recommended. DMSO: 20 mg/mL (39.58 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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