Powder: -20°C for 3 years | In solvent: -80°C for 1 year
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 53.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 143.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 489.00 | |
100 mg | In stock | $ 716.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 109.00 |
Description | XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases. |
Targets&IC50 | mTOR:9.9 nM |
Kinase Assay | Determination of Enzyme IC50 Values: IC50 values are determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled-enzyme format, according to the manufacturer's protocol (Z'-LYTE@biochemical assay). Kinase selectivity is determined using both the Z'-LYTE@ and Adapta@ kinase assay format. |
Molecular Weight | 455.5 |
Formula | C23H22FN3O4S |
CAS No. | 1251156-08-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 22 mg/mL (48.3 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
XL388 1251156-08-7 Metabolism PI3K/Akt/mTOR signaling PI3K P450 mTOR inhibit Mammalian target of Rapamycin XL-388 Inhibitor XL 388 inhibitor