Shopping Cart

Remove All

Your shopping cart is currently empty

ZD-0892

Select Batch

Purity:99.53%

Resource Download

COA HNMR HPLC LCMS

ZD-0892

Catalog No. T13389Cas No. 171964-73-1

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, inhibits human neutrophil elastase and porcine pancreatic elastase, reverses advanced pulmonary vascular disease produced in rats, and can be used to study chronic obstructive pulmonary disease (COPD) and peripheral vascular disease (PVD).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$119	In Stock
5 mg	$293	In Stock
10 mg	$483	In Stock
25 mg	$896	In Stock
50 mg	$1,230	In Stock

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	ZD-0892 is a selective and potent inhibitor of neutrophil elastase, inhibits human neutrophil elastase and porcine pancreatic elastase, reverses advanced pulmonary vascular disease produced in rats, and can be used to study chronic obstructive pulmonary disease (COPD) and peripheral vascular disease (PVD).
In vitro	Neutrophils incubated with ZD-0892 (20µM) for 1 hour were found to be resistant to superoxide, hypochlorite, hydrogen peroxide, hydroxyl radical and peroxynitrite-mediated degradation and had no effect on the formation of these oxidants by activated neutrophils.[3]
In vivo	Administration of ZD0892 to DBA/2 mice infected with EMC virus reduces myocardial elastolytic activity and coronary microvascular perfusion injury.ZD0892 reduces the pathological severity of myocardial lesions associated with viral myocarditis in mice[1].ZD-0892 reverses advanced pulmonary vascular disease produced in rats[2].

Chemical Properties

Molecular Weight	499.52
Formula	C24H32F3N3O5
Cas No.	171964-73-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 150 mg/mL (300.29 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0019 mL	10.0096 mL	20.0192 mL	100.0961 mL
5 mM	0.4004 mL	2.0019 mL	4.0038 mL	20.0192 mL
10 mM	0.2002 mL	1.0010 mL	2.0019 mL	10.0096 mL
20 mM	0.1001 mL	0.5005 mL	1.0010 mL	5.0048 mL
50 mM	0.0400 mL	0.2002 mL	0.4004 mL	2.0019 mL
100 mM	0.0200 mL	0.1001 mL	0.2002 mL	1.0010 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc