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AC1903

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Purity:98.33%

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COA HNMR HPLC

AC1903

Catalog No. T8528Cas No. 831234-13-0

AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.

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Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$64	In Stock
25 mg	$129	In Stock
50 mg	$213	In Stock
100 mg	$318	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock

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Product Introduction

Bioactivity

Description	AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
In vivo	AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.?TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases[1].
Animal Research	Twice-daily intraperitoneal injections of AC1903 (50 mg/kg) for 7 days suppressed severe proteinuria in AT1R Tg rats (Advanced)[1]

Chemical Properties

Molecular Weight	303.36
Formula	C19H17N3O
Cas No.	831234-13-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32.5 mg/mL (107.13 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2964 mL	16.4821 mL	32.9641 mL	164.8207 mL
5 mM	0.6593 mL	3.2964 mL	6.5928 mL	32.9641 mL
10 mM	0.3296 mL	1.6482 mL	3.2964 mL	16.4821 mL
20 mM	0.1648 mL	0.8241 mL	1.6482 mL	8.2410 mL
50 mM	0.0659 mL	0.3296 mL	0.6593 mL	3.2964 mL
100 mM	0.0330 mL	0.1648 mL	0.3296 mL	1.6482 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc