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AEG 3482
🥰Excellent
Catalog No. T21852Cas No. 63735-71-7
AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.
AEG 3482
🥰Excellent
Purity: 100%
Catalog No. T21852Cas No. 63735-71-7
AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $29 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $77 | In Stock | |
| 25 mg | $173 | In Stock | |
| 50 mg | $273 | In Stock | |
| 100 mg | $394 | In Stock | |
| 200 mg | $573 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25. |
| In vitro | AEG 3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ∼20 μM. AEG 3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells. AEG 3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner[1]. |
| Molecular Weight | 280.33 |
| Formula | C10H8N4O2S2 |
| Cas No. | 63735-71-7 |
| Smiles | NS(=O)(=O)c1nn2cc(nc2s1)-c1ccccc1 |
| Relative Density. | 1.75 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (713.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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