Shopping Cart

Remove All

Your shopping cart is currently empty

AF 12198 Acetate

Select Batch

Purity:95.27%

Resource Download

COA MS HPLC

AF 12198 Acetate

Catalog No. T21644L

AF 12198 Acetate is a novel low molecular weight antagonist of IL-1

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$697	In Stock
5 mg	$1,470	In Stock
10 mg	$1,980	In Stock
25 mg	$2,950	In Stock
50 mg	$3,980	In Stock
100 mg	$5,360	In Stock
1 mL x 10 mM (in DMSO)	$3,890	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "AF 12198 Acetate"

Product Introduction

Bioactivity

Description	AF 12198 Acetate is a novel low molecular weight antagonist of IL-1
In vitro	?In vitro, AF12198 inhibits IL-1-induced IL-8 production by human dermal fibroblasts with a half-maximal inhibition concentration or IC50 of 25 nM and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells with an IC50 of 9 nM[1].
In vivo	When given as an intravenous infusion to cynomolgus monkeys, AF12198 blocks ex vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6.?This is the first small molecule to show IL-1 receptor antagonist activity in vivo[1].?
Alias	AF 12198 Acetate (185413-30-3 Free base)

Chemical Properties

Molecular Weight	1955.17
Formula	C98H127N19O24
Cas No.

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (30.69 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5115 mL	2.5573 mL	5.1146 mL	25.5732 mL
5 mM	0.1023 mL	0.5115 mL	1.0229 mL	5.1146 mL
10 mM	0.0511 mL	0.2557 mL	0.5115 mL	2.5573 mL
20 mM	0.0256 mL	0.1279 mL	0.2557 mL	1.2787 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc