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AF 12198 Acetate
🥰Excellent
Catalog No. T21644L
Alias AF 12198 Acetate (185413-30-3 Free base)
AF 12198 Acetate is a novel low molecular weight antagonist of IL-1
AF 12198 Acetate
🥰Excellent
Purity: 95.27%
Catalog No. T21644LAlias AF 12198 Acetate (185413-30-3 Free base)
AF 12198 Acetate is a novel low molecular weight antagonist of IL-1
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $697 | In Stock | |
| 5 mg | $1,470 | In Stock | |
| 10 mg | $1,980 | In Stock | |
| 25 mg | $2,950 | In Stock | |
| 50 mg | $3,980 | In Stock | |
| 100 mg | $5,360 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $3,890 | In Stock |
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Purity:95.27%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AF 12198 Acetate is a novel low molecular weight antagonist of IL-1 |
| Targets&IC50 | IL-8:25 nM |
| In vitro | ?In vitro, AF12198 inhibits IL-1-induced IL-8 production by human dermal fibroblasts with a half-maximal inhibition concentration or IC50 of 25 nM and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells with an IC50 of 9 nM[1]. |
| In vivo | When given as an intravenous infusion to cynomolgus monkeys, AF12198 blocks ex vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6.?This is the first small molecule to show IL-1 receptor antagonist activity in vivo[1].? |
| Alias | AF 12198 Acetate (185413-30-3 Free base) |
| Molecular Weight | 1955.17 |
| Formula | C98H127N19O24 |
| Smiles | CC(O)=O.CC(C)C[C@@H](C(N)=O)NC([C@H]1N(C([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC2=CC=C(O)C=C2)N(C([C@H](CCC(N)=O)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CC4=CNC5=C4C=CC=C5)NC(CNC([C@H]6N(C([C@H]([C@H](O)C)NC([C@H](CC7=CNC8=C7C=CC=C8)NC([C@H](CCC(O)=O)NC([C@H](CC9=CC=CC=C9)NC(C)=O)=O)=O)=O)=O)CCC6)=O)=O)=O)=O)=O)C(C%10NCC%10)=O)=O)=O)=O)CCC1)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (30.69 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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