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AF-DX 384 free base
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Catalog No. T22555Cas No. 118290-26-9
Alias AFDX384 free base, AF-DX 384 (methanesulfonate)
AF-DX 384 free base is a selective and efficient M2 muscarinic acetylcholine receptor (M2 mAChR) and M4 muscarinic acetylcholine receptor (M4 mAChR) antagonist. It can be used for research on neurodegenerative diseases like Parkinson’s.
AF-DX 384 free base
😃Good
Catalog No. T22555Alias AFDX384 free base, AF-DX 384 (methanesulfonate)Cas No. 118290-26-9
AF-DX 384 free base is a selective and efficient M2 muscarinic acetylcholine receptor (M2 mAChR) and M4 muscarinic acetylcholine receptor (M4 mAChR) antagonist. It can be used for research on neurodegenerative diseases like Parkinson’s.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $83 | In Stock | |
| 5 mg | $223 | 35 days | |
| 10 mg | $323 | 35 days | |
| 25 mg | $695 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AF-DX 384 free base is a selective and efficient M2 muscarinic acetylcholine receptor (M2 mAChR) and M4 muscarinic acetylcholine receptor (M4 mAChR) antagonist. It can be used for research on neurodegenerative diseases like Parkinson’s. |
| Targets&IC50 | M4 mAChR:10 nM (Ki), M2 mAChR:6.03 nM (Ki) |
| In vitro | AF-DX 384 free base is an antagonist that selectively acts on M2 and M4 muscarinic acetylcholine receptors with Ki values of 6.03 nM and 10 nM, respectively. [1] |
| Alias | AFDX384 free base, AF-DX 384 (methanesulfonate) |
| Molecular Weight | 478.63 |
| Formula | C27H38N6O2 |
| Cas No. | 118290-26-9 |
| Smiles | O=C1NC2=CC=CN=C2N(C(=O)NCCN3CCCCC3CN(CCC)CCC)C=4C=CC=CC14 |
| Relative Density. | 1.144 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (10.45 mM), Sonication is recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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