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AGN 196996

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COA LCMS HNMR

AGN 196996

Catalog No. T10261Cas No. 958295-17-5

AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).

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Pack Size	Price	Availability
1 mg	$90	In Stock
5 mg	$222	In Stock
10 mg	$333	In Stock
25 mg	$576	In Stock
50 mg	$838	In Stock
100 mg	$1,230	In Stock
1 mL x 10 mM (in DMSO)	$235	In Stock

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Product Introduction

Bioactivity

Description	AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).
Targets&IC50	RARγ:8523 nM(Ki), RARα:2 nM(Ki), RARβ:1087 nM(Ki)
In vitro	AGN 196996 is a potent and selective RARα antagonist with a Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). RARα antagonist AGN 196996 shows no activity in transactivation assays but instead blocks the gene transcriptional activity induced by ATRA and other RAR agonists.[1]

Chemical Properties

Molecular Weight	482.32
Formula	C24H20BrNO5
Cas No.	958295-17-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 225.0 mg/mL (466.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0733 mL	10.3666 mL	20.7331 mL	103.6656 mL
5 mM	0.4147 mL	2.0733 mL	4.1466 mL	20.7331 mL
10 mM	0.2073 mL	1.0367 mL	2.0733 mL	10.3666 mL
20 mM	0.1037 mL	0.5183 mL	1.0367 mL	5.1833 mL
50 mM	0.0415 mL	0.2073 mL	0.4147 mL	2.0733 mL
100 mM	0.0207 mL	0.1037 mL	0.2073 mL	1.0367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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