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Ajmalicine

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Purity:96.9%

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COA CNMR MS HNMR HPLC

Ajmalicine

Catalog No. T8044Cas No. 483-04-5

Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。

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Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$98	In Stock
10 mg	$156	In Stock
25 mg	$262	In Stock
50 mg	$389	In Stock

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Product Introduction

Bioactivity

Description	Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity。
In vitro	Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1]. Ajmalicine inhibits contractions in a concentration-dependent manner, IC50=72.3 ± 22.5 μM[2]. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3].
In vivo	Ajmalicine blocks the pressor action of electrical stimulation and is active against sympathetic stimulation. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1].
Alias	Lamuran, Delta-Yohimbine, Raubasine, Ajmalicin

Chemical Properties

Molecular Weight	352.43
Formula	C21H24N2O3
Cas No.	483-04-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.5 mg/mL (7.09 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8374 mL	14.1872 mL	28.3744 mL	141.8721 mL
5 mM	0.5675 mL	2.8374 mL	5.6749 mL	28.3744 mL

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