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AMG 511

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COA HNMR

AMG 511

Catalog No. T14214Cas No. 1253573-53-3

AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease.

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Pack Size	Price	Availability
1 mg	$84	In Stock
2 mg	$109	In Stock
5 mg	$155	In Stock
10 mg	Inquiry	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$299	In Stock

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Product Introduction

Bioactivity

Description	AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K
In vitro	AMG 511 shows the inhibition of AKT (Ser473) phosphorylation in U87 malignant glioma (MG) cells with an IC50 of 4 nM[1].
In vivo	AMG 511 shows excellent in vivo efficacy and pharmacokinetic profile[1]. AMG 511 potently blocks the targeted PI3K pathway in a mouse liver pharmacodynamic model (3-30 mg/kg; p.o.). And it inhibits tumor growth in a U87 MG glioblastoma xenograft model (3-30 mg/kg; p.o.; daily; for 12 days)[1].

Chemical Properties

Molecular Weight	517.58
Formula	C22H28FN9O3S
Cas No.	1253573-53-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.33 mg/mL (64.40 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9321 mL	9.6603 mL	19.3207 mL	96.6034 mL
5 mM	0.3864 mL	1.9321 mL	3.8641 mL	19.3207 mL
10 mM	0.1932 mL	0.9660 mL	1.9321 mL	9.6603 mL
20 mM	0.0966 mL	0.4830 mL	0.9660 mL	4.8302 mL
50 mM	0.0386 mL	0.1932 mL	0.3864 mL	1.9321 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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