Shopping Cart
- Remove All
Your shopping cart is currently empty
Atpenin A5
🥰Excellent
Catalog No. T9714Cas No. 119509-24-9
Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), as well as an effective mKATP channel agonist and cardioprotective agent [1].
Atpenin A5
🥰Excellent
Purity: 97.33%
Catalog No. T9714Cas No. 119509-24-9
Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), as well as an effective mKATP channel agonist and cardioprotective agent [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $255 | In Stock | |
| 2 mg | $346 | In Stock | |
| 5 mg | $522 | In Stock | |
| 10 mg | $759 | In Stock | |
| 25 mg | $1,170 | In Stock | |
| 50 mg | $1,580 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Atpenin A5"
Tannic acid
Cited
Gallotannic acid
T08011401-55-4
Tannic acid (Gallotannic acid) is a novel hERG channel blocker.
- $41
Size
QTY
CitedIndapamide
Veroxil, Tertensif, Noranat
T149826807-65-8
Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
Inquiry
Minoxidil sulfate
U-58838, Minoxidil sulphate
T813583701-22-8
Minoxidil sulfate (U-58838) is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil.
- $31
Size
QTY
Hydrochlorothiazide
HCTZ
T144958-93-5
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
- $48
Size
QTY
Ursodeoxycholic acid Cited
Ursodiol, UDCA
T0700128-13-2
Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.
- $30
Size
QTY
CitedNifedipine Cited
Procardia XL, Procardia, BAY-a-1040, Adalat
T114621829-25-4
Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
- $45
Size
QTY
CitedHalothane
Narcotane, Anestan
T0954151-67-7
Halothane (Anestan) is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required.
- $45
Size
QTY
Cloperastine hydrochloride
HT-11 hydrochloride
T072314984-68-0
Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.
- $31
Size
QTY
Tetraethylammonium bromide
TEAB, TEA bromide
T836171-91-0
Tetraethylammonium bromide (TEA bromide) can selectively block potassium channels.
- $29
Size
QTY
Butamben
Butyl 4-aminobenzoate
T091694-25-7
Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
- $31
Size
QTY
(±)-Naringenin Cited
Salipurpol, Naringenine, Naringenin
TMS217167604-48-2
(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- $45
Size
QTY
CitedMinoxidil
U10858
T045138304-91-5
Minoxidil (U10858) is an orally administered vasodilator with hair growth stimulatory and antihypertensive effects.
- $50
Size
QTY
Select Batch
Purity:97.33%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), as well as an effective mKATP channel agonist and cardioprotective agent [1]. |
| In vitro | Atpenin A5 effectively inhibits submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, exhibiting IC50 values of 8.3 nM, 9.3 nM, and 8.5 nM, respectively. It acts as a potent, specific inhibitor of complex II. Moreover, at a concentration of 1 nM, Atpenin A5 (AA5) activates the mitochondrial ATP-sensitive potassium (mKATP) channel and offers protection against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes[1]. |
| In vivo | Atpenin A5, a potent succinate dehydrogenase (SDH) inhibitor, promotes cardiomyocyte mitosis and regeneration in the postnatal heart following myocardial infarction (MI). Mice injected with Atpenin A5 (100 μg/kg) showed increased myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls[2]. |
| Molecular Weight | 366.24 |
| Formula | C15H21Cl2NO5 |
| Cas No. | 119509-24-9 |
| Smiles | COc1[nH]c(=O)c(C(=O)[C@@H](C)C[C@H](C)[C@@H](Cl)CCl)c(O)c1OC |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (273.04 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Atpenin A5 | purchase Atpenin A5 | Atpenin A5 cost | order Atpenin A5 | Atpenin A5 chemical structure | Atpenin A5 in vivo | Atpenin A5 in vitro | Atpenin A5 formula | Atpenin A5 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.