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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $255 | In Stock | |
2 mg | $346 | In Stock | |
5 mg | $522 | In Stock | |
10 mg | $759 | In Stock | |
25 mg | $1,170 | In Stock | |
50 mg | $1,580 | In Stock |
Description | Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM). Atpenin A5 is also an effective mKATP channel agonist and cardioprotective agent[1]. |
In vitro | Atpenin A5 effectively inhibits submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, exhibiting IC50 values of 8.3 nM, 9.3 nM, and 8.5 nM, respectively. It acts as a potent, specific inhibitor of complex II. Moreover, at a concentration of 1 nM, Atpenin A5 (AA5) activates the mitochondrial ATP-sensitive potassium (mKATP) channel and offers protection against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes[1]. |
In vivo | Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). SDH inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected (100 μg/kg) mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls[2]. |
Molecular Weight | 366.24 |
Formula | C15H21Cl2NO5 |
Cas No. | 119509-24-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (273.04 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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