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AZD-9574
🥰Excellent
Catalog No. T9756Cas No. 2756333-39-6
AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
AZD-9574
🥰Excellent
Purity: 98.55%
Catalog No. T9756Cas No. 2756333-39-6
AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $117 | In Stock | |
| 2 mg | $169 | In Stock | |
| 5 mg | $289 | In Stock | |
| 10 mg | $463 | In Stock | |
| 25 mg | $818 | In Stock | |
| 50 mg | $1,170 | In Stock | |
| 100 mg | $1,560 | In Stock |
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Purity:98.55%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies. |
| In vitro | AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6[1]. |
| In vivo | In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice[1]. |
| Molecular Weight | 428.44 |
| Formula | C21H22F2N6O2 |
| Cas No. | 2756333-39-6 |
| Smiles | CNC(=O)c1ccc(N2CCN(Cc3ccc4nc(C)c(=O)[nH]c4c3F)CC2)c(F)n1 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: ＜1 mg/mL (insoluble or slightly soluble), Sonication and heating to 60℃ are recommended.  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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