Shopping Cart
- Remove All
Your shopping cart is currently empty
AZD5582
🥰Excellent
Catalog No. T14378Cas No. 1258392-53-8
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
AZD5582
🥰Excellent
Purity: 98.75%
Catalog No. T14378Cas No. 1258392-53-8
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $49 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "AZD5582"
Tributyrin
NSC-661583, NSC661583, NSC 661583
T1967660-01-5
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. It diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into cells in vivo, exhibiting potent proapoptotic, antiproliferative, and differentiation-inducing effects.
- $50
Size
QTY
Stavudine
Sanilvudine, NSC 163661, d4T, BMY-27857
T14043056-17-5
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
ApoptosisAutophagyHIV ProteaseNOD-like Receptor (NLR)Nucleoside Antimetabolite/AnalogReverse Transcriptase
- $33
Size
QTY
Dextran sulfate sodium salt (MW 4500-5500)
Cited
DSS, Dextran sulfate sodium salt (MW 4500-5500)
T136479011-18-1
Dextran sulfate sodium salt (MW 4500-5500) is an anhydrous glucose polymer with a molecular weight range of 4500-5500. It inhibits human immunodeficiency virus replication by preventing viral adsorption to host cells and is commonly used to model inflammatory bowel disease. The high negative charge from its sulfate groups damages the intestinal mucosal barrier, leading to intestinal barrier dysfunction, macrophage impairment, and bacterial flora disorder.
- $39
Size
QTY
CitedL-Ascorbic acid sodium salt
Vitamin C sodium salt, Sodium L-ascorbate, Sodium ascorbate, L-Ascorbic acid sodium, (+)-Sodium L-ascorbate
T6674134-03-2
L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
- $30
Size
QTY
Sodium 4-phenylbutyrate Cited
TriButyrate, Sodium Phenylbutyrate, Buphenyl
T15351716-12-7
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
- $38
Size
QTY
CitedL-Glutamic acid
glutamic acid, glutacid, (S)-Glutamic acid, (+)-L-Glutamic acid
T2A249756-86-0
L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
- $42
Size
QTY
L-Ascorbic acid Cited
Vitamin C, L-Ascorbate, L(+)-Ascorbic acid, Ascorbic acid
T092850-81-7
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
- $42
Size
QTY
CitedAcetylcysteine
Cited
N-Acetyl-L-cysteine, N-Acetylcysteine, N-Acetyl Cysteine, NAC, LNAC
T0875616-91-1
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.
- $33
Size
QTY
CitedSalicylic acid
2-Hydroxybenzoic acid
T064969-72-7
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
- $33
Size
QTY
5-Fluorouracil Cited
NSC 19893, Fluorouracil, 5-FU, 5-Fluoracil
T098451-21-8
5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.
- $30
Size
QTY
CitedMetronidazole Cited
Metronidazol, Flagyl, Anagiardil
T1079443-48-1
Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
- $30
Size
QTY
CitedMyricetin Cited
Cannabiscetin
T0579529-44-2
Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic, antioxidant, hepatoprotective, anti-tumor and anti-inflammatory activities.
- $30
Size
QTY
CitedSelect Batch
Purity:98.75%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis. |
| Targets&IC50 | XIAP:15 nM (IC50), CIAP2:21 nM (IC50), CIAP1:15 nM (IC50) |
| In vitro | AZD5582 (20 nM; 48 hours) inhibited cell viability by cooperating with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells[2]. In HCC827 NSCLC cells, AZD5582 (20 nM; 48 hours) induced apoptosis by activating cell death and caspase-3/-8 through co-treatment with IFNγ[2]. Additionally, AZD5582 (20 nM; 17 or 25 hours) down-regulated cIAP-1, activated RIPK1 (an upstream regulator of caspase-8), and initiated both extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, leading to the cleavage of caspase-3 and caspase-7[2]. |
| In vivo | AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) induces cIAP1 degradation and caspase 3 cleavage in tumor cells, leading to significant tumor resolution after two weeks. A medium dose (0.5 mg/kg) of AZD5582 degrades cIAP1 but requires additional time to achieve apoptosis-inducing effects[1]. |
| Molecular Weight | 1015.29 |
| Formula | C58H78N8O8 |
| Cas No. | 1258392-53-8 |
| Smiles | OC(=O)C(F)(F)F.CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1[C@@H](Cc2ccccc12)OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1 |
| Relative Density. | 1.26 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 66.25 mg/mL (65.25 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy AZD5582 | purchase AZD5582 | AZD5582 cost | order AZD5582 | AZD5582 chemical structure | AZD5582 in vivo | AZD5582 in vitro | AZD5582 formula | AZD5582 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.