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B-Raf IN 11
🥰Excellent
Catalog No. T19802Cas No. 918504-27-5
B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.
B-Raf IN 11
🥰Excellent
Purity: 99.46%
Catalog No. T19802Cas No. 918504-27-5
B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $30 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Questions
QThe detection results after adding the drug show no effect. Does this indicate a problem with the product quality?
AThe product quality is assured, All products have undergone two rigorous quality inspections. Structural confirmation is achieved through HNMR, while purity is determined by HPLC. However, the same inhibitor may yield different IC50 values and experimental outcomes due to variations in experimental materials (such as cells or animals). Therefore, it's not advisable to directly replicate methods in literature. Instead, establish concentration gradients tailored to your own experiments.
QHow to store the inhibitor solutions?
AAfter the stock solution is prepared, it is typically stored at -80°C and can be kept for over 1 year. It is recommended to aliquot to avoid repeated freeze-thaw cycles. For frequent use, it can be stored at 4°C for over a week.
QHow to store inhibitor products?
ASolid-form products can be stored at -20°C for more than 3 years.
Stock solutions are typically stored at -80°C and can be stored for more than 1 year. It is recommended to aliquot the product to avoid repeated freeze-thaw cycles.
For short-term storage, samples can be kept at 4°C for more than one week.
QWhat should I do if the product colors are different after multiple purchases?
AFirst, please confirm the batch number. If it's the same batch, please verify the product's color with our technical specialist. If they are from different batches, the color difference may result from variations in the manufacturing process. Factors such as operations, temperature, and duration during production could influence the color. If you have concerns about a specific batch, please download the corresponding quality inspection report from our official website. We take full responsibility for the quality.
QWhat should I do if the IC50 obtained for cell killing are significantly different from that presented on the your website?
AThe IC50 you obtain refers to the cell proliferation inhibition assay (half maximal inhibitory concentration), which is different in meaning from the IC50 on our website. The IC50 often refers to the inhibition rate of the target without cell experiments, which is generally determined through kinase or protein purification experiments, and is commonly reported in nanomolar concentrations. However, the IC50 obtained from cell proliferation inhibition assays refers to the half-maximal lethality of the cells, which involves cellular metabolism and penetration, so the concentration is usually higher.
Furthermore, the effect of the same compound on different cell models varies. It is recommended to try increasing the incubation volume and extending the incubation time.
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Purity:99.46%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | B-Raf IN 11 is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer. |
| Molecular Weight | 458.28 |
| Formula | C17H14BrF2N3O3S |
| Cas No. | 918504-27-5 |
| Smiles | C(=O)(C=1C=2C(NC1)=NC=C(Br)C2)C3=C(F)C(NS(CCC)(=O)=O)=CC=C3F |
| Relative Density. | 1.689 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (130.92 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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