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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $148 | In Stock | |
5 mg | $372 | In Stock | |
10 mg | $556 | In Stock | |
25 mg | $896 | In Stock | |
50 mg | $1,220 | In Stock | |
100 mg | $1,650 | In Stock | |
1 mL x 10 mM (in DMSO) | $397 | In Stock |
Description | BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependent on the E3 ligase SIAH1, demonstrating notable antitumor activity[1][2]. |
Targets&IC50 | BCL6 BTB:≤ 3 nM |
In vitro | BI-3802 shows an IC50 of 43 nM for the cellular BCL6[1]. BI-3802 increases the interaction between BCL6 and SIAH1 (EC50 = 64 nM)[2]. |
Molecular Weight | 484.98 |
Formula | C24H29ClN6O3 |
Cas No. | 2166387-65-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (10.31 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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