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BMS-986141
🥰Excellent
Catalog No. T63966Cas No. 1478711-48-6
Alias UDM-003183
BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.
BMS-986141
🥰Excellent
Purity: 99.11%
Catalog No. T63966Alias UDM-003183Cas No. 1478711-48-6
BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $787 | In Stock | |
| 5 mg | $1,580 | In Stock | |
| 10 mg | $1,970 | In Stock | |
| 25 mg | $2,820 | In Stock | |
| 50 mg | $3,780 | In Stock | |
| 100 mg | $5,130 | In Stock |
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Purity:99.11%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects. |
| Targets&IC50 | PAR4:2.2 nM |
| In vitro | With an IC50 value of 2.2 nM, BMS-986141 (compound 49) inhibits platelet aggregation induced by PAR4 agonist peptide in a concentration-dependent manner, ranging from 0 to 1 μM[1]. |
| In vivo | BMS-986141 (compound 49), administered at a dose of 0.5 mg/kg, demonstrates excellent anti-thrombotic efficacy in cynomolgus monkeys. Additionally, it shows a slight but significant prolongation of KBT (kidney bleeding time)[1][2]. |
| Alias | UDM-003183 |
| Molecular Weight | 561.63 |
| Formula | C27H23N5O5S2 |
| Cas No. | 1478711-48-6 |
| Smiles | O(CC=1N=C(SC1)C2=CC=C(C(N(C)C)=O)C=C2)C3=C4C(OC(=C4)C5=CN6C(=N5)SC(OC)=N6)=CC(OC)=C3 |
Storage & Solubility Information
| Storage | store at low temperature | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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