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BMS-986235

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Purity:99.65%

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COA HPLC HNMR

BMS-986235

Catalog No. T39789Cas No. 2253947-47-4

BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.

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Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$372	In Stock
10 mg	$556	In Stock
25 mg	$896	In Stock
50 mg	$1,220	In Stock
100 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock

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Product Introduction

Bioactivity

Description	BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.
In vitro	BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation[1].
In vivo	In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L•h, and 24%, respectively[1].
Alias	BMS-986235, LAR-1219

Chemical Properties

Molecular Weight	361.34
Formula	C18H17F2N3O3
Cas No.	2253947-47-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (262.91 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7675 mL	13.8374 mL	27.6748 mL	138.3738 mL
5 mM	0.5535 mL	2.7675 mL	5.5350 mL	27.6748 mL
10 mM	0.2767 mL	1.3837 mL	2.7675 mL	13.8374 mL
20 mM	0.1384 mL	0.6919 mL	1.3837 mL	6.9187 mL
50 mM	0.0553 mL	0.2767 mL	0.5535 mL	2.7675 mL
100 mM	0.0277 mL	0.1384 mL	0.2767 mL	1.3837 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Keywords

InhibitormacrophagephagocytosisheartBMS 986235LAR 1219chemotaxisfailureinhibitinflammationneutrophilBMS986235LAR1219