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BMS-986235

🥰Excellent
Catalog No. T39789Cas No. 2253947-47-4
Alias LAR-1219, BMS-986235

BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM for hFPR2 and 3.4 nM for mFPR2. BMS-986235 can be used in studies on the prevention of heart failure.

BMS-986235

BMS-986235

🥰Excellent
Purity: 99.65%
Catalog No. T39789Alias LAR-1219, BMS-986235Cas No. 2253947-47-4
BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM for hFPR2 and 3.4 nM for mFPR2. BMS-986235 can be used in studies on the prevention of heart failure.
Pack SizePriceAvailabilityQuantity
1 mg$64In Stock
5 mg$156In Stock
10 mg$255In Stock
25 mg$519In Stock
50 mg$732In Stock
100 mg$990In Stock
200 mg$1,330In Stock
1 mL x 10 mM (in DMSO)$169In Stock
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Purity:99.65%
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Product Introduction

Bioactivity
Description
BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM for hFPR2 and 3.4 nM for mFPR2. BMS-986235 can be used in studies on the prevention of heart failure.
Targets&IC50
FPR1 (human):2800 nM (EC50), FPR2 (mouse):3.4 nM (EC50), FPR2 (human):0.41 nM (EC50)
In vitro
BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation[1].
In vivo
In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L•h, and 24%, respectively[1].
AliasLAR-1219, BMS-986235
Chemical Properties
Molecular Weight361.34
FormulaC18H17F2N3O3
Cas No.2253947-47-4
SmilesCOc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2)c(F)c1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 95 mg/mL (262.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7675 mL13.8374 mL27.6748 mL138.3738 mL
5 mM0.5535 mL2.7675 mL5.5350 mL27.6748 mL
10 mM0.2767 mL1.3837 mL2.7675 mL13.8374 mL
20 mM0.1384 mL0.6919 mL1.3837 mL6.9187 mL
50 mM0.0553 mL0.2767 mL0.5535 mL2.7675 mL
100 mM0.0277 mL0.1384 mL0.2767 mL1.3837 mL

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