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Bobcat339 hydrochloride is a selective 10 11 translocation (TET) dioxygenase inhibitor that inhibits TET1 and TET2.Bobcat339 hydrochloride induces TET3 protein degradation and also stimulates the expression of AGRP, NPY, and VGAT in a TET3-dependent manner in mouse and human neuronal cells. VGAT expression, which can be used to study transient anorexia nervosa.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $119 | In Stock | |
5 mg | $198 | In Stock | |
10 mg | $297 | In Stock | |
25 mg | $566 | In Stock | |
50 mg | $858 | In Stock | |
100 mg | $1,240 | In Stock | |
200 mg | $1,670 | In Stock | |
1 mL x 10 mM (in DMSO) | $226 | In Stock |
Description | Bobcat339 hydrochloride is a selective 10 11 translocation (TET) dioxygenase inhibitor that inhibits TET1 and TET2.Bobcat339 hydrochloride induces TET3 protein degradation and also stimulates the expression of AGRP, NPY, and VGAT in a TET3-dependent manner in mouse and human neuronal cells. VGAT expression, which can be used to study transient anorexia nervosa. |
Targets&IC50 | TET1:33 μM, TET2:73 μM |
In vitro | Bobcat339 hydrochloride is a potent and selective cytosine-based TET enzyme inhibitor, which significantly reduced the overall intracellular level of 5hmC by inhibiting TET enzyme activity in HT-22 cells at a concentration of 10 μM for 24 h. The IC50 of Bobcat339 hydrochloride for TET1 and TET2 were 33 μM and 73 μM, respectively. [1] |
Molecular Weight | 334.2 |
Formula | C16H13Cl2N3O |
Cas No. | 2436747-44-1 |
Smiles | Cl.O=C1N=C(N)C(Cl)=CN1C2=CC=CC(=C2)C=3C=CC=CC3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (299.22 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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