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Bobcat339

🥰Excellent
Catalog No. T5198Cas No. 2280037-51-4

Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.

Bobcat339

Bobcat339

🥰Excellent
Purity: 98.76%
Catalog No. T5198Cas No. 2280037-51-4
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$76In Stock
25 mg$163In Stock
50 mg$263In Stock
100 mg$388In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:98.76%
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Product Introduction

Bioactivity
Description
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
Targets&IC50
TET2:73 μM (cell free), TET1:33 μM (cell free)
In vitro
HT-22 cells were treated with 10 μM Bobcat339 in 1% DMSO for 24 hrs and lysed. Cells treated with Bobcat339 had significantly reduced global 5hmC levels as compared to vehicle control.
Chemical Properties
Molecular Weight297.74
FormulaC16H12ClN3O
Cas No.2280037-51-4
SmilesNc1nc(=O)n(cc1Cl)-c1cccc(c1)-c1ccccc1
Relative Density.1.33 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (151.14 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3586 mL16.7932 mL33.5864 mL167.9318 mL
5 mM0.6717 mL3.3586 mL6.7173 mL33.5864 mL
10 mM0.3359 mL1.6793 mL3.3586 mL16.7932 mL
20 mM0.1679 mL0.8397 mL1.6793 mL8.3966 mL
50 mM0.0672 mL0.3359 mL0.6717 mL3.3586 mL
100 mM0.0336 mL0.1679 mL0.3359 mL1.6793 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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