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Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $47 | In Stock | |
10 mg | $76 | In Stock | |
25 mg | $163 | In Stock | |
50 mg | $263 | In Stock | |
100 mg | $388 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
Targets&IC50 | TET2:73 μM (cell free), TET1:33 μM (cell free) |
In vitro | HT-22 cells were treated with 10 μM Bobcat339 in 1% DMSO for 24 hrs and lysed. Cells treated with Bobcat339 had significantly reduced global 5hmC levels as compared to vehicle control. |
Molecular Weight | 297.74 |
Formula | C16H12ClN3O |
Cas No. | 2280037-51-4 |
Smiles | Nc1nc(=O)n(cc1Cl)-c1cccc(c1)-c1ccccc1 |
Relative Density. | 1.33 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (151.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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