tet2

Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33 73 uM for TET1 2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.

TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases. With its unique properties, TFMB-(S)-2-HG holds great promise for advancing research in the field of acute myeloid leukemia (AML).

Bobcat339 hydrochloride can be used in the field of epigenetics and as a starting point for new therapeutics targeting DNA methylation and gene transcription. Bobcat339 hydrochloride is a potent and selective cytosine-based TET enzyme inhibitor with the IC50 values of 33 μM and 73 μM for TET1 and TET2, respectively [1].