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C75

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Purity:98.84%

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COA HNMR HPLC

C75

Catalog No. T10657Cas No. 218137-86-1

C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).

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Pack Size	Price	Availability
1 mg	$41	In Stock
2 mg	$59	In Stock
5 mg	$119	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Product Introduction

Bioactivity

Description	C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).
Targets&IC50	PC3 cells:35 μM
In vitro	C75 (10-50 μM) reduces the growth of LNCaP spheroids in a concentration-dependent manner (IC50: 50 μM). (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and produces anorexia. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity [2].
In vivo	C75 (i.p.) blocks fasting-induced c-Fos expression in the arcuate nucleus, lateral hypothalamic area, and paraventricular nucleus. C75 (30 mg/kg, i.p.) inhibits the food intake of mice by ≥95% within 2 h[3]. C75-treated DIO mice have a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA [4].
Alias	C-75

Chemical Properties

Molecular Weight	254.32
Formula	C14H22O4
Cas No.	218137-86-1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 75.6 mg/mL (297.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9321 mL	19.6603 mL	39.3205 mL	196.6027 mL
5 mM	0.7864 mL	3.9321 mL	7.8641 mL	39.3205 mL
10 mM	0.3932 mL	1.9660 mL	3.9321 mL	19.6603 mL
20 mM	0.1966 mL	0.9830 mL	1.9660 mL	9.8301 mL
50 mM	0.0786 mL	0.3932 mL	0.7864 mL	3.9321 mL
100 mM	0.0393 mL	0.1966 mL	0.3932 mL	1.9660 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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Keywords

C 75C75

C75

C75

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