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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $1,050 | 35 days |
Description | Capsorubin is a carotenoid with a variety of biological activities. capsorubin inhibited lipid peroxidation induced by 2,2′-azino(2,4-dimethylvaleronitrile) (AMVN) at a concentration of 167 μM. capsorubin (1 μM) reduced uvb-induced DNA strand breaks and apoptosis in human dermal fibroblasts. formation. It also inhibited the activation of ebvirus early antigen (EBV-EA) induced by 12-carnosine 13-acetate fobo in Raji cells. |
In vitro | Preincubation of human dermal fibroblasts (HDF) with capsorubin significantly counteracted UVB-induced cytotoxicity at doses between 0 and 300 mJ cm(-2). Pretreatment of HDF with capsorubin (1 μM) significantly decreased the formation of DNA strand breaks following irradiation with UVB light. Capsorubin studied decreased caspase-3 cleavage (a marker for UVB-induced apoptosis), however, caspase-dependent PARP-1 cleavage was not affected suggesting that the remaining caspase activity is sufficient to promote UVB-induced apoptosis. It is conceivable that capsorubin selectively interferes with cellular responses activated by UVB-mediated damage. Our findings indicate that capsorubin exhibits similar properties to lutein and could be used as a dietary supplement to improve natural photoprotection.[1] |
Molecular Weight | 600.87 |
Formula | C40H56O4 |
Cas No. | 470-38-2 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: Soluble DMF: Soluble |
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