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CBFβ Inhibitor

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Purity:96.50%

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COA LCMS HNMR

CBFβ Inhibitor

Catalog No. T22195Cas No. 493028-20-9

CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.

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Pack Size	Price	Availability
1 mg	$37	In Stock
2 mg	$51	In Stock
5 mg	$78	In Stock
10 mg	$141	In Stock
25 mg	$313	In Stock
50 mg	$428	In Stock
100 mg	$538	In Stock
200 mg	$777	In Stock

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Product Introduction

Bioactivity

Description	CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.
In vitro	The ELISA results have shown that CBFβ Inhibitor is very effective in inhibiting the CBFβ-Runx1 interaction (IC50: 3.2 μM). In the leukemia cell line ME-1 expressing CBFβ-SMMHC, CBFβ Inhibitor reduced cell proliferation dose-dependently. Treatment with CBFβ Inhibitor for 3 days showed an increase in apoptotic cells. Treatment with CBFβ Inhibitor for 14 days individually or with all-trans-retinoic acid (ATRA) resulted in cells with greater variation in size and shape, lower nuclear-to-cytoplasmic ratio, increased folding, and lobation of nuclei, and more clumped chromatin. All of these morphology changes are consistent with differentiation to more mature forms. CBFβ Inhibitor at 50 μM increased proliferation of Hep-G2 cells. CBFβ treatment with Inhibitor resulted in a statistically significant reduction in Runx1 bound to DNA [1].
Alias	5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine

Chemical Properties

Molecular Weight	234.32
Formula	C12H14N2OS
Cas No.	493028-20-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 25 mg/mL

DMSO: 55 mg/mL (234.72 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2677 mL	21.3383 mL	42.6767 mL	213.3834 mL
5 mM	0.8535 mL	4.2677 mL	8.5353 mL	42.6767 mL
10 mM	0.4268 mL	2.1338 mL	4.2677 mL	21.3383 mL
20 mM	0.2134 mL	1.0669 mL	2.1338 mL	10.6692 mL
50 mM	0.0854 mL	0.4268 mL	0.8535 mL	4.2677 mL
100 mM	0.0427 mL	0.2134 mL	0.4268 mL	2.1338 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc