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CGS 15435

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Purity:99.63%

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COA HPLC HNMR LCMS

CGS 15435

Catalog No. T10783Cas No. 95853-92-2

CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase.

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Pack Size	Price	Availability
1 mg	$197	In Stock
5 mg	$478	In Stock
10 mg	$654	In Stock
25 mg	$990	In Stock
50 mg	$1,330	In Stock
100 mg	$1,750	In Stock
1 mL x 10 mM (in DMSO)	$558	In Stock

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Product Introduction

Bioactivity

Description	CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase.
In vitro	CGS 15435 inhibited the formation of PGE2 (IC50:1200 μM), PGI2 synthetase (IC50:90 μM) and 5-lipoxygenase (IC50:60 μM).[1]
In vivo	The effect of CGS 15435 was long lasting, as the increase of plasma TxB2 levels was prevented even 24 hours after the administration of CGS 15435. CGS 15435 inhibited the formation of TxB2 significantly at 4, 6, 12 and 24 h after administration. Administration of CGS 15435 0.25 or 24 h before arachidonic acid (AA) did not increase TxB2 in surviving animals (4/4 and 5/6, respectively). The final TxB2 level in CGS15435A(pretreatment for 0.25 and 24 h) groups was significantly lower than that in arachidonic acid (AA) and daxibon (pretreatment for 2 h) groups.[1]

Chemical Properties

Molecular Weight	356.85
Formula	C20H21ClN2O2
Cas No.	95853-92-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.57 mg/mL (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8023 mL	14.0115 mL	28.0230 mL	140.1149 mL
5 mM	0.5605 mL	2.8023 mL	5.6046 mL	28.0230 mL

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