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CGS 15943
🥰Excellent
Catalog No. T14944Cas No. 104615-18-1
CGS 15943 is an orally bioavailable non-xanthine antagonist of the Adenosine Receptor. In transfected CHO cells, its Ki values for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM, respectively.
CGS 15943
🥰Excellent
Purity: 99.63%
Catalog No. T14944Cas No. 104615-18-1
CGS 15943 is an orally bioavailable non-xanthine antagonist of the Adenosine Receptor. In transfected CHO cells, its Ki values for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 37 € | In Stock | |
| 5 mg | 86 € | In Stock | |
| 10 mg | 126 € | In Stock | |
| 25 mg | 211 € | In Stock | |
| 50 mg | 316 € | In Stock | |
| 100 mg | 473 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 88 € | In Stock |
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CitedSelect Batch
Purity:99.63%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CGS 15943 is an orally bioavailable non-xanthine antagonist of the Adenosine Receptor. In transfected CHO cells, its Ki values for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM, respectively. |
| Targets&IC50 | A2B receptor:16 nM (ki), p110δ:8.47 μM, A3 receptor:51 nM (ki), A2A receptor:4.2 nM (ki), p110γ:1.1 μM, A1 receptor:3.5 nM (ki) |
| In vitro | CGS 15943 inhibits the kinase activity of the class IB PI3K isoform p110γ (IC50: 1.1 μM). CGS 15943 shows slight inhibition on p110δ (IC50: 8.47 μM). CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells. CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells[3]. |
| Molecular Weight | 285.69 |
| Formula | C13H8ClN5O |
| Cas No. | 104615-18-1 |
| Smiles | Nc1nc2ccc(Cl)cc2c2nc(nn12)-c1ccco1 |
| Relative Density. | 1.72 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12.22 mg/mL (42.77 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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