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CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $233 | 35 days | |
10 mg | $365 | 35 days | |
25 mg | $858 | 35 days | |
50 mg | $1,590 | 35 days |
Description | CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). |
Targets&IC50 | 5-HT2A:6.81 (pEC50), 5-HT2B:7.19 (pEC50), 5-HT2C:9.96 (pEC50) |
In vitro | Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. Thus, the present results demonstrate that the 5-HT2C agonist, CP-809101, has a pharmacological profile similar to that of the atypical antipsychotics with low extrapyramidal symptom liability. |
Molecular Weight | 304.77 |
Formula | C15H17ClN4O |
Cas No. | 479683-64-2 |
Relative Density. | 1.265 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: Soluble |
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