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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $56 | In Stock | |
2 mg | $79 | In Stock | |
5 mg | $122 | In Stock | |
10 mg | $197 | In Stock | |
25 mg | $447 | In Stock | |
50 mg | $659 | In Stock | |
100 mg | $939 | In Stock | |
1 mL x 10 mM (in DMSO) | $135 | In Stock |
Description | CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM. |
In vitro | CRT0273750 is also shown to inhibit the migration of 4T1 cells with an EC50 of 0.025μM[1]. CRT0273750 shows high potency in both the biochemical (IC50 = 0.01 μM) and plasma choline release assay(IC50 = 0.014 μM)[1]. |
In vivo | CRT0273750 treatment shows the Cmax, AUC and t1/2 values of 3.8 μM, 3.2 μM.h and 1.4 h, respectively and shows a proportional increase[1].CRT0273750 has a moderate blood clearance, with value of 41 mL/min/kg[1]. |
Alias | CRT 0273750, CRT-0273750 |
Molecular Weight | 502.92 |
Formula | C25H22ClF3N4O2 |
Cas No. | 1979939-16-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/ml(397.68 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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