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Devapamil

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Purity:100%

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COA HNMR HPLC LCMS

Devapamil

Catalog No. T68055Cas No. 92302-55-1

Devapamil (Devapamilo) is a phenylalkylamine that blocks L-type calcium currents from the inner side of membrane cells in a use-dependent manner.

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Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$180	In Stock
10 mg	$260	In Stock
25 mg	$506	In Stock
50 mg	$680	In Stock
100 mg	$968	In Stock
500 mg	$1,930	In Stock

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Product Introduction

Bioactivity

Description	Devapamil (Devapamilo) is a phenylalkylamine that blocks L-type calcium currents from the inner side of membrane cells in a use-dependent manner.
In vitro	Devapamil (3 μM) reduced L-type calcium currents (ICa) to 16.1 +/- 8.6%, 11 +/- 8.9%, and 9.3 +/- 6% of control, respectively. Intracellular application of the same substances, via the patch pipette filled with 30 μM of devapamil, failed to depress ICa. The quaternary derivatives of the phenylalkylamines (30 microM) were ineffective both when applied extracellularly or intracellularly. It is suggested that phenylalkylamines block ICa in ventricular myocytes by acting on a binding site of the calcium channel molecule located at the outer surface of the cell membrane.[3]
Alias	Devapamilo, Devapamilum

Chemical Properties

Molecular Weight	424.58
Formula	C26H36N2O3
Cas No.	92302-55-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (117.76 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3553 mL	11.7763 mL	23.5527 mL	117.7634 mL
5 mM	0.4711 mL	2.3553 mL	4.7105 mL	23.5527 mL
10 mM	0.2355 mL	1.1776 mL	2.3553 mL	11.7763 mL
20 mM	0.1178 mL	0.5888 mL	1.1776 mL	5.8882 mL
50 mM	0.0471 mL	0.2355 mL	0.4711 mL	2.3553 mL
100 mM	0.0236 mL	0.1178 mL	0.2355 mL	1.1776 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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