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Diflunisal

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Purity:99.66%

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COA LCMS HPLC HNMR

Diflunisal

Catalog No. T0808Cas No. 22494-42-4

Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.

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Pack Size	Price	Availability
25 mg	$30	In Stock
50 mg	$43	In Stock
100 mg	$61	In Stock
200 mg	$89	In Stock
500 mg	$148	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.
In vitro	Diflunisal, an FDA-approved drug containing a salicylic acid substructure, inhibited CBP/p300 more potently than salicylate. Diflunisal exhibits anti-tumor activity against a specific leukemia carrying a t(8;21) translocation, a tumor previously reported to be dependent on p300 in vitro and in vivo[2].
In vivo	Diflunisal-mediated kinetic stabilization of TTR(Rate-limiting transthyretin) should ameliorate TTR amyloidoses, provided that the nonsteroidal anti-inflammatory drug liabilities can be managed clinically[3].
Cell Research	HEK293T cells are transfected with expression vectors for WT p300 or catalitycally inactive mutant. 24 hr after transfection, cells are treated with diflunisal as indicated for 24 hr. H2B acetylation is measured by Western Blot using specified antibodies. Experiments are repeated four times. (Only for Reference)
Alias	Flovacil, Dolobid, MK-647, Fluniget, Dolobis

Chemical Properties

Molecular Weight	250.2
Formula	C13H8F2O3
Cas No.	22494-42-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (199.84 mM)

Ethanol: 20 mg/mL (79.94 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.9968 mL	19.9840 mL	39.9680 mL	199.8401 mL
5 mM	0.7994 mL	3.9968 mL	7.9936 mL	39.9680 mL
10 mM	0.3997 mL	1.9984 mL	3.9968 mL	19.9840 mL
20 mM	0.1998 mL	0.9992 mL	1.9984 mL	9.9920 mL
50 mM	0.0799 mL	0.3997 mL	0.7994 mL	3.9968 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0400 mL	0.1998 mL	0.3997 mL	1.9984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc