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Difluprednate

🥰Excellent
Catalog No. T6472Cas No. 23674-86-4
Alias Myser, Epitopic, CM 9155

Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.

Difluprednate

Difluprednate

🥰Excellent
Purity: 99.58%
Catalog No. T6472Alias Myser, Epitopic, CM 9155Cas No. 23674-86-4
Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.
Pack SizePriceAvailabilityQuantity
10 mg$33In Stock
25 mg$50In Stock
50 mg$73In Stock
100 mg$103In Stock
200 mg$186In Stock
500 mg$297In Stock
1 mL x 10 mM (in DMSO)$40In Stock
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Purity:99.58%
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Product Introduction

Bioactivity
Description
Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.
In vitro
The difluprednate emulsion formulation begin by suspending DFBA in a variety of oils (castor, cottonseed, medium-chain fatty acid triglyceride, oleic, olive, peanut, and soybean). [1] Difluprednate ophthalmic emulsion's active metabolite, 6α,9-difluoroprednisolone 17-butyrate (DFB), has the lowest Ki value (611 nM) for the glucocorticoid receptor and is significantly more active than prednisolone, which has a Ki value of 3.4 nM. [2]
In vivo
Difluprednate emulsion is rapidly deacetylated in the aqueous humor to difluoroprednisolone butyrate (DFB) in rats and rabbits, the drug's active metabolite, which has a similar corticosteroid activity profile. Radio-labeled difluprednate is instilled in the right eyes of pigmented rabbits in a separate study examining DFBA excretion. Difluprednate (0.05% emulsion) results in higher aqueous humor concentrations than the suspension form in the eyes of rabbits. Difluprednate concentrations ≥0.01% shows a statistically significant inhibition of inflammation compared to saline in a rabbit model, with the anti-inflammatory response proceeding in a dose-dependent manner. Difluprednate suppresses uveitis in all three concentration (0.002%, 0.01%, and 0.05%) in a dose-dependent manner in rats, and difluprednate 0.05% shows statistically superior anti-inflammatory activity compared to Betamethasone (0.1%). [1]
AliasMyser, Epitopic, CM 9155
Chemical Properties
Molecular Weight508.55
FormulaC27H34F2O7
Cas No.23674-86-4
Smiles[H][C@@]12CC[C@](OC(=O)CCC)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
Relative Density.1.29 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 24 mg/mL (47.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (98.32 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.9664 mL9.8319 mL19.6637 mL98.3187 mL
5 mM0.3933 mL1.9664 mL3.9327 mL19.6637 mL
10 mM0.1966 mL0.9832 mL1.9664 mL9.8319 mL
20 mM0.0983 mL0.4916 mL0.9832 mL4.9159 mL
DMSO
1mg5mg10mg50mg
50 mM0.0393 mL0.1966 mL0.3933 mL1.9664 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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