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E7016
🥰Excellent
Catalog No. T61189Cas No. 902128-92-1
Alias GPI 21016
E7016 (GPI 21016) is an orally available PARP inhibitor that inhibits DNA repair and enhances tumor cell radiosensitivity both in vitro and in vivo.
E7016
🥰Excellent
Purity: 98.16%
Catalog No. T61189Alias GPI 21016Cas No. 902128-92-1
E7016 (GPI 21016) is an orally available PARP inhibitor that inhibits DNA repair and enhances tumor cell radiosensitivity both in vitro and in vivo.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $132 | In Stock | |
| 5 mg | $328 | In Stock | |
| 10 mg | $496 | In Stock | |
| 25 mg | $795 | In Stock | |
| 50 mg | $1,090 | In Stock | |
| 100 mg | $1,560 | In Stock |
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Purity:98.16%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | E7016 (GPI 21016) is an orally available PARP inhibitor that inhibits DNA repair and enhances tumor cell radiosensitivity both in vitro and in vivo. |
| In vitro | E7016 (3 μM) enhances radiosensitization by an increase in the number of cells undergoing mitotic catastrophe and not an increase in the number of cells undergoing apoptosis[1]. E7016 inhibits PARP by mimicking NAD+[2]. |
| In vivo | Administration of E7016 (40 mg/kg; oral gavage) to mice bearing U251 xenografts enhances the effectiveness of the Temozolomide/radiation combination. Mice treated with E7016/irradiation/Temozolomide have an additional growth delay of six days compared with the combination of irradiation/Temozolomide in vivo[1]. |
| Alias | GPI 21016 |
| Molecular Weight | 349.38 |
| Formula | C20H19N3O3 |
| Cas No. | 902128-92-1 |
| Smiles | OC1CCN(Cc2ccc3oc4cccc5c4c(n[nH]c5=O)c3c2)CC1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (64.4 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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