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EACC
🥰Excellent
Catalog No. T11142Cas No. 864941-31-1
EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts autophagic flux.
EACC
🥰Excellent
Purity: 98.89%
Catalog No. T11142Cas No. 864941-31-1
EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts autophagic flux.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $50 | In Stock | |
| 5 mg | $118 | In Stock | |
| 10 mg | $209 | In Stock | |
| 25 mg | $358 | In Stock | |
| 50 mg | $509 | In Stock | |
| 100 mg | $702 | In Stock | |
| 200 mg | $947 | In Stock |
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Purity:98.89%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts autophagic flux. |
| In vitro | EACC inhibits autophagy by blocking the loading of SNARE Stx17 onto autophagosomes, without affecting RABs, tethers, and lysosomal SNARE. It specifically impedes their interaction with LC3 and Stx17, thus halting autophagosome-lysosome fusion. Importantly, endo-lysosomal function remains unaffected by EACC. |
| Molecular Weight | 369.37 |
| Formula | C13H11N3O6S2 |
| Cas No. | 864941-31-1 |
| Smiles | CCOC(=O)NC(=O)c1ccsc1NC(=O)c1ccc(s1)[N+]([O-])=O |
| Relative Density. | 1.565 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (13.54 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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