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EB1

EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits the phosphorylation of eIF4E.

Catalog No. T73582Cas No. 42951-68-8

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Purity:99.82%

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COA HNMR HPLC

EB1

Catalog No. T73582Cas No. 42951-68-8

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Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$163	In Stock
10 mg	$238	In Stock
25 mg	$395	In Stock
50 mg	$593	In Stock
100 mg	$846	In Stock
500 mg	$2,350	In Stock
1 g	$3,490	In Stock

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Product Introduction

Bioactivity

Description	EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits the phosphorylation of eIF4E.
Targets&IC50	HepG2 cells:0.74 μM, MNK2:9.4 μM, MNK1:0.69 μM, MCF-7 cells:5.18 μM
In vitro	EB1, in a dose-dependent manner (1.3-40 μM; 24 hours), inhibits the phosphorylation of eIF4E[1]. At doses of 2.5-40 μM (72 hours), EB1 exhibits dose-dependent cytotoxicity against tumor cells and induces apoptosis[1]. When directly acting on MNK kinase at concentrations of 5 μM, 10 μM, and 20 μM (24 hours), EB1 does not interfere with the activation of upstream signals such as p38 activation (p-p38) and the phosphorylation of its downstream effector HSP27[1]. Compound 14 (EB1) inhibits cancer cells HepG2 and MCF-7 with IC50 values of 0.74 μM and 5.18 μM, respectively[2].

Chemical Properties

Molecular Weight	286.33
Formula	C₁₈H₁₄N₄
Cas No.	42951-68-8

Storage & Solubility Information

Storage

store at low temperature | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (174.62 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4925 mL	17.4624 mL	34.9247 mL	174.6237 mL
5 mM	0.6985 mL	3.4925 mL	6.9849 mL	34.9247 mL
10 mM	0.3492 mL	1.7462 mL	3.4925 mL	17.4624 mL
20 mM	0.1746 mL	0.8731 mL	1.7462 mL	8.7312 mL
50 mM	0.0698 mL	0.3492 mL	0.6985 mL	3.4925 mL
100 mM	0.0349 mL	0.1746 mL	0.3492 mL	1.7462 mL

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EB1

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