Shopping Cart
- Remove All
Your shopping cart is currently empty
EB1
🥰Excellent
Catalog No. T73582Cas No. 42951-68-8
EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits the phosphorylation of eIF4E.
EB1
🥰Excellent
Purity: 99.82%
Catalog No. T73582Cas No. 42951-68-8
EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits the phosphorylation of eIF4E.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $68 | In Stock | |
| 5 mg | $163 | In Stock | |
| 10 mg | $238 | In Stock | |
| 25 mg | $395 | In Stock | |
| 50 mg | $593 | In Stock | |
| 100 mg | $846 | In Stock | |
| 500 mg | $2,350 | In Stock | |
| 1 g | $3,490 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "EB1"
MK2-IN-3 hydrate
MK-2 Inhibitor III
T120581186648-22-5
MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
- $30
Size
QTY
CGP 57380
MNK1 Inhibitor
T6440522629-08-9
CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases.
- $39
Size
QTY
AZ7550
T135641421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
- $133
Size
QTY
QL-X-138
T389601469988-63-3In house
QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK. The IC50 values of QL-X-138 are 9.4 nM for BTK, 107.4 nM for MNK1, 26 nM for MNK2, and 3.5 μM against Dengue 2. QL-X-138 is used in the study of B-cell malignancies and B-cell malignant tumors.
- $193
Size
QTY
QL-X-138 HCl
QL-X-138 HCl(1469988-63-3 Free base)
T38960LIn house
QL-X-138 HCl is a novel selective and highly potent BTK/MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-138 HCl has anti-dengue virus 2 activity and shows anti-proliferative activity in acute myeloid leukemia cells. QL-X-138 HCl can be used to study lymphoma and leukemia.
- $195
Size
QTY
MNK1/2-IN-5
T607331426928-20-2
MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.
- $58
Size
QTY
SLV-2436
SLV 2436, SEL201-88, SEL-201
T44242095704-43-9
SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).
- $74
Size
QTY
Tomivosertib
Cited
eFT508
T34681849590-01-7
Tomivosertib (eFT508) is a potent and highly selective MNK1 and MNK2 inhibitor with an IC50 value of 1-2 nM.
- $59
Size
QTY
CitedDS12881479
T606812373065-59-7
DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].
- $101
Size
QTY
Select Batch
Purity:99.82%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits the phosphorylation of eIF4E. |
| Targets&IC50 | MNK2:9.4 μM, HepG2 cells:0.74 μM, MNK1:0.69 μM, MCF-7 cells:5.18 μM |
| In vitro | EB1, in a dose-dependent manner (1.3-40 μM; 24 hours), inhibits the phosphorylation of eIF4E[1]. At doses of 2.5-40 μM (72 hours), EB1 exhibits dose-dependent cytotoxicity against tumor cells and induces apoptosis[1]. When directly acting on MNK kinase at concentrations of 5 μM, 10 μM, and 20 μM (24 hours), EB1 does not interfere with the activation of upstream signals such as p38 activation (p-p38) and the phosphorylation of its downstream effector HSP27[1]. Compound 14 (EB1) inhibits cancer cells HepG2 and MCF-7 with IC50 values of 0.74 μM and 5.18 μM, respectively[2]. |
| Molecular Weight | 286.33 |
| Formula | C18H14N4 |
| Cas No. | 42951-68-8 |
| Smiles | NC=1C2=C(C=C(N=C2NN1)C3=CC=CC=C3)C4=CC=CC=C4 |
Storage & Solubility Information
| Storage | store at low temperature | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (174.62 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy EB1 | purchase EB1 | EB1 cost | order EB1 | EB1 chemical structure | EB1 in vitro | EB1 formula | EB1 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.