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EBI-2511

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Purity:99.01%

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COA HPLC HNMR

EBI-2511

Catalog No. T15194Cas No. 2098546-05-3

EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).

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Pack Size	Price	Availability
1 mg	$60	In Stock
5 mg	$147	In Stock
10 mg	$228	In Stock
25 mg	$478	In Stock
50 mg	$690	In Stock
100 mg	$992	In Stock

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Product Introduction

Bioactivity

Description	EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).
In vitro	EBI-2511 obviously decreases cellular H3K27me3 levels in a dose-dependent manner (an approximate IC50: 8 nM) and it is 3-fold more potent than EPZ-6438. In addition to Pfeffier cell line, EBI-2511 was shown active against WSU-DLCL2 ( IC50: 55 nM) [1].
In vivo	EBI-2511 shows a dose-dependent inhibition on the tumor growth, resulting in 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg) reduction in tumor size. There is no significant changes in body weights of all treatment groups are observed. At the same dosage level, EBI-2511 displays a superior anti-tumor efficacy to EPZ-6438 (P<0.01) [1].

Chemical Properties

Molecular Weight	576.77
Formula	C34H48N4O4
Cas No.	2098546-05-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (8.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7338 mL	8.6690 mL	17.3379 mL	86.6897 mL
5 mM	0.3468 mL	1.7338 mL	3.4676 mL	17.3379 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc